Prediction of irritancy in the human skin irritancy model and occupational setting

Irritancy of the skin disinfectant n-propanol.

Hand disinfection with short-chain aliphatic alcohols, so-called "rub-ins" is the method of choice for cross-infection prevention in health care environments, but their irritant potential is not well known. Skin tolerance is a major compliance factor, and a high proportion of health care workers suffer from low-grade irritant contact dermatitis. Therefore, assessment of the irritancy of the ski...

RR601 Irritancy and sensitisation

Draize Eye Irritancy Test Rabbits

Household products, shampoos, pesticides, weed killers, even riot control gases, are just some of the products tested for irritancy in the eyes of conscious rabbits. The Draize test, introduced in 1944, is cruelly simple. The substance under test is sprayed or instilled into one eye of an albino rabbit. Generally no pain relief is given and the test often proceeds for 7 days during which the co...

The effect of adhesive dressing edges on cutaneous irritancy and skin barrier function.

OBJECTIVE To assess the effect of repeated application and removal of adhesive edges from wound-care products on cutaneous irritancy and barrier function in normal volunteer subjects. METHOD This was a study using a 'repeat-insult patch test'. Adhesive edges from six commonly used wound-care products were applied continuously to the same site (six applications over a 14-day period) in 30 norm...

Comedogenicity and irritancy of commonly used ingredients in skin care products

A survey, using the rabbit ear, of the comedogenicity and irritancy of several groups of skin care products indicates that many contain follicular and surface pithelial irritating ingredients. These ingredients fall into several chemical classes. Certain generalizations can be deduced by examining the results: (1) medium-chain-length fatty acids are more potent than shortor long-chain fatty aci...